Cohort Description

The study includes 492 patients with first-episode psychosis or bipolar disorder, 492 individuals at high risk for psychosis or bipolar disorder, and 492 healthy controls between 15 to 35 years of age. Subjects will be recruited from multiple sites including Pusan National University Yangsan Hospital (PI: Tae Young Lee), Inje University Pusan Paik Hospital (PI: Do Un Chung), Kosin University Gospel Hospital (PI: Ho Chan Kim), Pusan National University (PI: Sunhae Sul). MRI data will be collected at Pusan National University Yangsan Hospital using a 3T Siemens Vida MR scanner. Subjects are assessed on a yearly basis after the baseline, 3 months, six months and one year. We would like to develop a model for predicting transition to psychosis and bipolar disorder by using various biological markers, and present a pluripotent diagnostic system covering various mental disorders at the same time in the direction of quantitative psychiatry.

Demographics: Family Interview for Genetics Studies (FIGS), Hollingshead Four-Factor Index of Socioeconomic Status (HFIS), Annett Hand Preference Questionnaire (AHPQ)

Clinical: Structured Clinical Interview for the DSM-5-Research Version (SCID-5-RV), Structured Interview for Prodromal Syndrome (SIPS), Comprehensive Assessment of At-Risk Mental States (CAARMS), Bipolar Prodrome Symptom Interview and Scale–Prospective (BPSS-P), Positive and Negative Syndrome Scale (PANSS), Brief Negative Symptom Scale (BNSS), Young’s mania rating scale (YMRS), Calgary Depression Scale for Schizophrenia (CDSS), Global Assessment of Functioning (GAF), Social and Occupational Functioning Assessment Scale (SOFAS), Global Functioning: Social and Role Scales (GF).

Self Reports: Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), Aberrant Salience Inventory (ASI), Beck Cognitive Insight Scale (BCIS), The Barratt Impulsiveness Scale – 11 (BIS-11), Childhood trauma and abuse questionnaire (CTAQ), Connor-Davidson Resilience Scale 10-Item (CD-RISC-10), Difficulties in Emotion Regulation Scale (DERS), Social Functioning Scale (SFS)

Cognition: Wechsler Adult Intelligence Scale (WAIS), Digit Span, Spatial Working Memory (SWM),  Stroop Task, Wisconsin Card Sorting Test (WCST), Trail Making Test (TMT), Controlled Oral Word Association Test (COWAT), California Verbal Learning Test (CVLT), Rey Complex Figure Test and Recognition Trial (RCFT), Auditory Continuous Performance Test (ACPT), Bilateral Complex Finger Tapping (BCFT), Smooth Pursuit Task, Internal, Personal and Situational Attributions Questionnaire (IPSAQ), Reading the Mind in the Eyes Test (RMET), PENN Emotion Recognition Test (ER-40).

Imaging:

  • sMRI: T1w (MPRAGE) and T2w (SPACE) = 0.8mm isotropic resolution
  • dMRI: 1.8mm isotropic, TR = 3800ms, b-value = 1000(30), 2000(30) and 3000(30)
  • fMRI: 2mm isotropic resolution, TR = 1000ms
  • MRS: VTE PR STEAM for anterior cingulate, left hippocampus
  • Neuromelanin: 0.75mm isotropic, TR = 54ms, 

Blood: Cortisol, C-reactive protein (CRP), Interleukin 6 (IL-6)