Tae Young Lee

He is an Associate Professor in the Department of Psychiatry at Pusan National University Yangsan Hospital. He was previously a Research Professor at Seoul National University Hospital and a Senior Researcher at Seoul National University College of Medicine. He earned his MD, MS degree in Psychiatry at Kosin University, and Yonsei University College of Medicine. He received his PhD degree in Biomedical Engineering at Hanyang University. He is interested in developing a model that uses neuroimaging to diagnose schizophrenia and predict transition to psychosis. He is also interested in developing a treatment program that enhances a human’s social functioning.
contact to: tylee@pusan.ac.kr

Publications

2020

Prediction of psychosis: Model development and internal validation of a personalized risk calculator. Lee TY, Hwang WJ, Kim NS, Park I, Roh K, Moon S, Oh S, Lee J, Kim M, Woo CW, Kwon JS. Psychol Med. 2020 Dec

Distinct neural networks associated with obsession and delusion: a connectome-wide association study. Lee TY, Jung WH, Kwak YB, Yoon YB, Lee J, Kim M, Kim E, Kwon JS. Psychol Med. 2020 Jan 30:1-9.

In vivo gamma-aminobutyric acid -A/benzodiazepine receptor availability and genetic liability in asymptomatic individuals with high genetic loading of schizophrenia: A [11C]flumazenil positron emission tomography study. Lee J, Yoon YB, Cho KIK, Seo S, Lee JS, Jeong JM, Kim E, Kim M, Lee TY, Kwon JS. Hum Psychopharmacol. 2020 Nov 13:e2766

Defining data-driven subgroups of obsessive-compulsive disorder with different treatment responses based on resting-state functional connectivity. Kwak S, Kim M, Kim T, Kwak Y, Oh S, Lho SK, Moon SY, Lee TY, Kwon JS. Transl Psychiatry. 2020 Oct 26;10(1):359.

Neural bases of the clinical and neurocognitive differences between earlyand late-onset obsessive–compulsive disorder. Kim T, Kwak S, Hur JW, Lee J, Shin WG, Lee TY, Kim M, Kwon JS. J Psychiatry Neurosci. 2020 Jul 1;45(4):234-242.

Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study. Lee TY, Lee J, Lee HJ, Lee Y, Rhee SJ, Park DY, Paek MJ, Kim EY, Kim E, Roh S, Jung HY, Kim M, Kim SH, Han D, Ahn YM, Ha K, Kwon JS. Front Psychiatry. 2020 Apr 21;11:340

Intact thalamic microstructure in asymptomatic relatives of schizophrenia patients with high genetic loading. Hwang WJ, Cho KIK, Kwak YB, Lee J, Kim M, Lee TY, Kwon JS. Schizophr Res. 2020 Aug 3:S0920-9964(20)30394-7.

Comparison of serum protein profiles between major depressive disorder and bipolar disorder. Rhee SJ, Han D, Lee Y, Kim H, Lee J, Lee K, Shin H, Kim H, Lee TY, Kim M, Kim SH, Ahn YM, Kwon JS, Ha K. BMC Psychiatry. 2020 Apr 3;20(1):145.

Enhanced Attentional Network by Short-Term Intensive Meditation. Kwak S, Kim SY, Bae D, Hwang WJ, Cho KIK, Lim KO, Park HY, Lee TY, Kwon JS. Front Psychol. 2020 Feb 7;10:3073.

Functional Connectivity of the Striatum as a Neural Correlate of Symptom Severity in Patient with Obsessive-Compulsive Disorder. Park J, Kim T, Kim M, Lee TY, Kwon JS. Psychiatry Investig. 2020 Feb;17(2):87-95.

Resting-state functional connectivity of the striatum predicts improvement in negative symptoms and general functioning in patients with first-episode psychosis: A 1-year naturalistic follow-up study. Oh S, Kim M, Kim T, Lee TY, Kwon JS. Aust N Z J Psychiatry. 2020 May;54(5):509-518.

Auditory P300 as a Neurophysiological Correlate of Symptomatic Improvement by Transcranial Direct Current Stimulation in Patients With Schizophrenia: A Pilot Study. Kim M, Lee TH, Hwang WJ, Lee TY, Kwon JS. Clin EEG Neurosci. 2020 Jul;51(4):252-258.

2019

Neural bases of the clinical and neurocognitive differences between early and late-onset obsessive–compulsive disorder. Kim T, Kwak S, Hur JW, Lee J, Shin WG, Lee TY, Kim M, Kwon JS. J Psychiatry Neurosci. 2019 Nov 25;45(1):190028.

Functional connectivity of the raphe nucleus as a predictor of the response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder. Kim M, Kwak S, Yoon YB, Kwak YB, Kim T, Cho KIK, Lee TY, Kwon JS. Neuropsychopharmacology. 2019 Nov;44(12):2073-2081.

Global and Specific Profiles of Executive Functioning in Prodromal and Early Psychosis. Hwang WJ, Lee TY, Shin WG, Kim M, Kim J, Lee J, Kwon JS. Front Psychiatry. 2019 May 21;10:356.

The Immediate and Sustained Positive Effects of Meditation on Resilience Are Mediated by Changes in the Resting Brain. Kwak S, Lee TY, Jung WH, Hur JW, Bae D, Hwang WJ, Cho KIK, Lim KO, Kim SY, Park HY, Kwon JS. Front Hum Neurosci. 2019 Mar 26;13:101.

Adjunctive use of anti-inflammatory drugs for schizophrenia: A meta-analytic investigation of randomized controlled trials. Cho M, Lee TY, Kwak YB, Yoon YB, Kim M, Kwon JS. Aust N Z J Psychiatry. 2019 Aug;53(8):742-759.

Effect of tDCS on Aberrant Functional Network Connectivity in Refractory Hallucinatory Schizophrenia: A Pilot Study. Yoon YB, Kim M, Lee J, Cho KIK, Kwak S, Lee TY, Kwon JS. Psychiatry Investig. 2019 Mar;16(3):244-248.

Disturbed thalamocortical connectivity in unaffected relatives of schizophrenia patients with a high genetic loading. Cho KIK, Kim M, Yoon YB, Lee J, Lee TY, Kwon JS. Aust N Z J Psychiatry. 2019 Sep;53(9):889-895.

Validation of the Korean Version of the Prodromal Questionnaire-Brief Version in Non-Help-Seeking Individuals. Jang YE, Lee TY, Hur JW, Kwon JS. Psychiatry Investig. 2019 Feb;16(2):109-114.

Early Identification of Psychiatric Disorders. Lee TY, Kim M, Kwon JS. Adv Exp Med Biol. 2019;1192:341-352.

A pilot study investigating the effect of transcranial direct current stimulation on the electrophysiological correlates of working memory in patients with schizophrenia. Moon SY, Kim M, Hwang WJ, Lee TY, Kwon JS. Psychiatry Res Neuroimaging. 2019 Feb 28;284:9-12.

Reduced cortical thickness in subjects at clinical high risk for psychosis and clinical attributes. Kwak YB, Kim M, Cho KIK, Lee J, Lee TY, Kwon JS. Aust N Z J Psychiatry. 2019 Mar;53(3):219-227.

Functional and Structural Connectivity of the Cerebellar Nuclei With the Striatum and Cerebral Cortex in First-Episode Psychosis. Lee KH, Oh H, Suh JS, Cho KIK, Yoon YB, Shin WG, Lee TY, Kwon JS. J Neuropsychiatry Clin Neurosci. 2019 Spring;31(2):143-151.

Microstructural Changes in Higher-Order Nuclei of the Thalamus in Patients With First-Episode Psychosis. Cho KIK, Kwak YB, Hwang WJ, Lee J, Kim M, Lee TY, Kwon JS. Biol Psychiatry. 2019 Jan 1;85(1):70-78.

2018

민세리, 이태영, 곽유빈, 권준수. 초발 정신병 환자에서 기저핵 구조물 부피의 패턴분석. 생물정신의학. 2018 May 1;25(2):38-43.

Thalamo-cortical system involving higher-order nuclei in patients with first-episode psychosis. Cho KIK, Kwak YB, Hwang WJ, Lee J, Kim M, Lee TY, Kwon JS. BMB Rep. 2018 Sep;51(9):427-428.

Beyond Domain-Specific Expertise: Neural Signatures of Face and Spatial Working Memory in Baduk (Go Game) Experts. Jung WH, Lee TY, Yoon YB, Choi CH, Kwon JS. Front Hum Neurosci. 2018 Aug 7;12:319.

Cerebellar Structural Abnormalities Associated With Cognitive Function in Patients With First-Episode Psychosis. Kim T, Lee KH, Oh H, Lee TY, Cho KIK, Lee J, Kwon JS. Front Psychiatry. 2018 Jul 3;9:286.

Lower glutamate level in temporo-parietal junction may predict a better response to tDCS in schizophrenia. Lee J, Yoon YB, Wijtenburg SA, Rowland LM, Chen H, Gaston FE, Song IC, Cho KIK, Kim M, Lee TY, Kwon JS. Schizophr Res. 2018 Nov;201:422-423.

Modulation of Electrophysiology by Transcranial Direct Current Stimulation in Psychiatric Disorders: A Systematic Review. Kim M, Kwak YB, Lee TY, Kwon JS. Psychiatry Investig. 2018 May;15(5):434-444.

Predicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity. Kim M, Lee TH, Yoon YB, Lee TY, Kwon JS. Schizophr Bull. 2018 Apr 6;44(3):575-583.

Aberrant within- and between-network connectivity of the mirror neuron system network and the mentalizing network in first episode psychosis. Choe E, Lee TY, Kim M, Hur JW, Yoon YB, Cho KK, Kwon JS. Schizophr Res. 2018 Sep;199:243-249.

Higher extrinsic and lower intrinsic connectivity in resting state networks for professional Baduk (Go) players. Sohn WS, Lee TY, Kwak S, Yoon YB, Kwon JS. Brain Behav. 2017 Oct 30;7(12):e00853.

Early referral and comorbidity as possible causes of the declining transition rate in subjects at clinical high risk for psychosis. Lim KO, Lee TY, Kim M, Chon MW, Yun JY, Kim SN, Kwon JS. Early Interv Psychiatry. 2018 Aug;12(4):596-604.

Genetic variation in cytokine genes and risk for transition to psychosis among individuals at ultra-high risk. Bousman CA, Lee TY, Kim M, Lee J, Mostaid MS, Bang M, An SK, Everall IP, Pantelis C, Kwon JS. Schizophr Res. 2018 May;195:589-590.

The effects of four days of intensive mindfulness meditation training (Templestay program) on resilience to stress: a randomized controlled trial. Hwang WJ, Lee TY, Lim KO, Bae D, Kwak S, Park HY, Kwon JS. Psychol Health Med. 2018 Jun;23(5):497-504.

Can We Predict Psychosis Outside the Clinical High-Risk State? A Systematic Review of Non-Psychotic Risk Syndromes for Mental Disorders. Lee TY, Lee J, Kim M, Choe E, Kwon JS. Schizophr Bull. 2018 Feb 15;44(2):276-285.

The effect of transcranial direct current stimulation on auditory hallucination in patients with schizophrenia. Lee TY, Lee J, Kim M, Kwon JS. Schizophr Res. 2018 Feb;192:489-490.

The effect of tDCS on auditory hallucination and P50 sensory gating in patients with schizophrenia: A pilot study. Kim M, Yoon YB, Lee TH, Lee TY, Kwon JS. Schizophr Res. 2018 Feb;192:469-470.

Decomposing P300 into correlates of genetic risk and current symptoms in schizophrenia: An inter-trial variability analysis. Kim M, Lee TH, Kim JH, Hong H, Lee TY, Lee Y, Salisbury DF, Kwon JS. Schizophr Res. 2018 Feb;192:232-239.

2017

Brain network characteristics separating individuals at clinical high risk for psychosis into normality or psychosis. Choi SH, Kyeong S, Cho KIK, Yun JY, Lee TY, Park HY, Kim SN, Kwon JS. Schizophr Res. 2017 Dec;190:107-114.

Is There an Association Between Mismatch Negativity and Cortical Thickness in Schizophrenia Patients? Seol JJ, Kim M, Lee KH, Hur JW, Cho KIK, Lee TY, Chung CK, Kwon JS. Clin EEG Neurosci. 2017 Nov;48(6):383-392.

Brain Structural Networks Associated with Intelligence and Visuomotor Ability. Yoon YB, Shin WG, Lee TY, Hur JW, Cho KIK, Sohn WS, Kim SG, Lee KH, Kwon JS. Sci Rep. 2017 May 19;7(1):2177.

Node Identification Using Inter-Regional Correlation Analysis for Mapping Detailed Connections in Resting State Networks. Sohn WS, Lee TY, Yoo K, Kim M, Yun JY, Hur JW, Yoon YB, Seo SW, Na DL, Jeong Y, Kwon JS. Front Neurosci. 2017 May 1;11:238.

Reconsidering Clinical Staging Model: A Case of Genetic High Risk for Schizophrenia. Lee TY, Kim M, Kim SN, Kwon JS. Psychiatry Investig. 2017 Jan;14(1):107-109.

Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis. Kim M, Cho KI, Yoon YB, Lee TY, Kwon JS. Clin Neurophysiol. 2017 Feb;128(2):331-339.

2016

Psychosis research in Asia: advantage from low prevalence of cannabis use. Lee TY, Kwon JS. NPJ Schizophr. 2016 Dec 13;2:1.

Longitudinal change in neurocognition and its relation to symptomatic and functional changes over 2years in individuals at clinical high-risk for psychosis. Shin YS, Kim SY, Lee TY, Hur JW, Shin NY, Kim SN, Shin MS, Kwon JS. Schizophr Res. 2016 Jul;174(1-3):50-57.

Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification. Fusar-Poli P, Cappucciati M, Borgwardt S, Woods SW, Addington J, Nelson B, Nieman DH, Stahl DR, Rutigliano G, Riecher-Rössler A, Simon AE, Mizuno M, Lee TY, Kwon JS, Lam MM, Perez J, Keri S, Amminger P, Metzler S, Kawohl W, Rössler W, Lee J, Labad J, Ziermans T, An SK, Liu CC, Woodberry KA, Braham A, Corcoran C, McGorry P, Yung AR, McGuire PK. JAMA Psychiatry. 2016 Feb;73(2):113-20.

Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS. Fusar-Poli P, Cappucciati M, Rutigliano G, Lee TY, Beverly Q, Bonoldi I, Lelli J, Kaar SJ, Gago E, Rocchetti M, Patel R, Bhavsar V, Tognin S, Badger S, Calem M, Lim K, Kwon JS, Perez J, McGuire P. Psychiatry J. 2016;2016:7146341.

Individualized covariance profile of cortical morphology for auditory hallucinations in first-episode psychosis. Yun JY, Kim SN, Lee TY, Chon MW, Kwon JS. Hum Brain Mapp. 2016 Mar;37(3):1051-65.

Disruption of effective connectivity from the dorsolateral prefrontal cortex to the orbitofrontal cortex by negative emotional distraction in obsessive-compulsive disorder. Han HJ, Jung WH, Yun JY, Park JW, Cho KK, Hur JW, Shin NY, Lee TY, Kwon JS. Psychol Med. 2016 Apr;46(5):921-32.

Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis. Cho KI, Shenton ME, Kubicki M, Jung WH, Lee TY, Yun JY, Kim SN, Kwon JS. Schizophr Bull. 2016 May;42(3):723-31.

2015

Baseline putamen volume as a predictor of positive symptom reduction in patients at clinical high risk for psychosis: A preliminary study. Hong SB, Lee TY, Kwak YB, Kim SN, Kwon JS. Schizophr Res. 2015 Dec;169(1-3):178-185.

Altered Fronto-Temporal Functional Connectivity in Individuals at Ultra-High-Risk of Developing Psychosis. Yoon YB, Yun JY, Jung WH, Cho KI, Kim SN, Lee TY, Park HY, Kwon JS. PLoS One. 2015 Aug 12;10(8):e0135347.

Auditory P300 as a predictor of short-term prognosis in subjects at clinical high risk for psychosis. Kim M, Lee TY, Lee S, Kim SN, Kwon JS. Schizophr Res. 2015 Jul;165(2-3):138-44.

Away from home: the brain of the wandering mind as a model for schizophrenia. Shin DJ, Lee TY, Jung WH, Kim SN, Jang JH, Kwon JS. Schizophr Res. 2015 Jun;165(1):83-9.

Social cognitive functioning in prodromal psychosis: A meta-analysis. Lee TY, Hong SB, Shin NY, Kwon JS. Schizophr Res. 2015 May;164(1-3):28-34.

Factors contributing to the duration of untreated prodromal positive symptoms in individuals at ultra-high risk for psychosis. Chon MW, Lee TY, Kim SN, Huh MJ, Park HY, Lee CR, Shin NY, Kwon JS. Schizophr Res. 2015 Mar;162(1-3):64-6.

2014

Effects of the functioning and antipsychotic use on clinical high risk for psychosis: a response to Yung et al. Lee TY, Kim SN, Chon MW, Kwon JS. Schizophr Res. 2014 Oct;159(1):254-5.

Symptomatic and functional remission of subjects at clinical high risk for psychosis: a 2-year naturalistic observational study. Lee TY, Kim SN, Correll CU, Byun MS, Kim E, Jang JH, Kang DH, Yun JY, Kwon JS. Schizophr Res. 2014 Jul;156(2-3):266-71.

Neurocognitive function as a possible marker for remission from clinical high risk for psychosis. Lee TY, Shin YS, Shin NY, Kim SN, Jang JH, Kang DH, Kwon JS. Schizophr Res. 2014 Mar;153(1-3):48-53.

The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder. Shin DJ, Jung WH, He Y, Wang J, Shim G, Byun MS, Jang JH, Kim SN, Lee TY, Park HY, Kwon JS. Biol Psychiatry. 2014 Apr 15;75(8):606-14.

The crisis of minimal self-awareness in schizophrenia: a meta-analytic review. Hur JW, Kwon JS, Lee TY, Park S. Schizophr Res. 2014 Jan;152(1):58-64.

Cognitive functioning in obsessive-compulsive disorder: a meta-analysis. Shin NY, Lee TY, Kim E, Kwon JS. Psychol Med. 2014 Apr;44(6):1121-30.

2013

Exploring the brains of Baduk (Go) experts: gray matter morphometry, resting-state functional connectivity, and graph theoretical analysis. Jung WH, Kim SN, Lee TY, Jang JH, Choi CH, Kang DH, Kwon JS. Front Hum Neurosci. 2013 Oct 2;7:633.

Impact of the BDNF Val66Met Polymorphism on Regional Brain Gray Matter Volumes: Relevance to the Stress Response. Kim SN, Kang DH, Yun JY, Lee TY, Jung WH, Jang JH, Kwon JS. Psychiatry Investig. 2013 Jun;10(2):173-9.

Neural correlate of impulsivity in subjects at ultra-high risk for psychosis. Lee TY, Kim SN, Jang JH, Shim G, Jung WH, Shin NY, Kwon JS. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:165-9.

2012

Early intervention in psychosis: Insights from Korea. Kwon JS, Byun MS, Lee TY, An SK. Asian J Psychiatr. 2012 Mar;5(1):98-105.

2010

Bone Density in Chronic Schizophrenia With Long-Term Antipsychotic Treatment: Preliminary Study. Lee TY, Chung MY, Chung HK, Choi JH, Kim TY, So HS. Psychiatry Investig. 2010 Dec;7(4):278-84.

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